The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.
Our team is excited to hire a highly motivated and interactive upper level scientist, with strong bioinformatics skills, experience in mass spectrometry-based proteomics data analysis, wet lab bench experience in analytical chemistry or molecular biology, and a publication (in peer-reviewed journals) record of accomplishment. The candidate will work closely as part of our translational proteomics team to plan experiments, process samples, generate high-quality data, and integrate and analyze datasets. The position includes drafting manuscripts for publication and giving oral presentations; thus a demonstrated track record of peer-reviewed journal publications, as well as excellent English written and oral presentation skills are required.
The work environment is highly collaborative and productive, requiring effective inter-personal communication skills, the capability to focus on multiple tasks and meet milestones, and the ability to function as part of a team- independently with minimal supervision. The candidate will contribute to the team both bioinformatically and at the bench, as needed. The work is quantitative, and attention to detail and the ability to follow standard operating protocols (SOP) are critical.
Analyze proteomic (mass spectrometry) and genomic datasets and contribute to interpreting the results to discern clinical or biological insights from high quality proteomics and proteogenomic datasets
Think independently about new results, connect them to domain knowledge, and formulate novel and testable hypotheses to glean clinical or biological insights; communicate new ideas to the team frequently and effectively (i.e., an interactive thought leader)
Apply computational methods and develop tools to interpret biological data and solve key problems in proteomics and proteogenomics-based research
Work with collaborating statisticians to ensure rigor in data analytics and interpretation
Generate high quality samples for proteomics analysis, and possibly also generate proteomic data
Collaborate with others to develop new methods (SOPs) and tools that support research objectives
Prepare and deliver presentations (oral and poster)
Prepare and publish scientific manuscripts (in peer-reviewed journals) and reports
Minimum of Master’s degree or equivalent and 5+ years experience in Chemistry, Biochemistry, Molecular Biology, or related discipline
Previous track record as co-author on published manuscripts in scientific journals
Ability to read and critically evaluate scientific literature related to team projects
Ability to think independently about new results, connect them to domain knowledge, and formulate novel and testable hypotheses to glean clinical or biological insights
Previous hands-on bench experience in analytical chemistry, biochemistry, or molecular biology
Familiarity with mass spectrometry fundamentals and associated data (discovery and targeted LC-MRM-MS)
Proficiency with MS Office programs (Word, Powerpoint, Excel, and Access)
Previous experience with MaxQuant, X!Tandem, SpectrumMill, MSGF, or other mass spectrometry search engines
Previous experience with Panorama, Skyline, or other Multiple Reaction Monitoring mass spectrometry software
Familiarity with genomics fundamentals and associated data (DNA and RNA sequencing, CNV, SNP, microarray datasets)
Previous experience with software tools such as R, Matlab, SAS, MS Access or SQL
Ability to multi-task efficiently in an highly interactive team environment
Must be comfortable in a milestone-driven environment, with quarterly objectives
Excellent English verbal and written communication/writing skills
PhD and 5+ years experience in Chemistry, Biochemistry, Molecular Biology, or related discipline
Previous experience in a CLIA or clinical lab environment
Previous experience with the mechanisms in cancer biology, DNA damage response, or immunotherapy a bonus
Internal Number: 11531
About Fred Hutchinson Cancer Research Center
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
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