The laboratory of Dr. Konrad Talbot at Loma Linda University Medical Center is seeking a full-time postdoctoral molecular biologist to conduct research on newly identified molecular mechanisms of brain insulin resistance and its treatment in Alzheimer’s disease (AD) using novel antidiabetics (i.e., incretin receptor agonists) on human postmortem tissue and animal models of the disorder. The research is funded by a new 5-year NIH grant to Dr. Talbot, the PI, and his collaborators at CUNY, UCLA, and the University of Washington. Given that brain insulin resistance can cause or exacerbate core brain pathologies and cognitive symptoms of AD, these novel antidiabetics have the potential to be among the first clinically effective therapeutics for AD. The work is expected to lead to new clinical trials in a few years.
A Ph.D. in neuroscience or a related field focusing on molecular biology is required, as are well developed and documented skills in cell culture, physiology, and pharmacology. One or two years of postdoctoral training is preferable, but not necessary. The position requires a highly motivated person working closely with the PI to understand his research aims, priorities, and deadlines, but with a clear ability to work independently in educating himself/herself on the literature relevant to the laboratory’s work, proposing new ideas on how to advance that work, designing experiments to test those ideas, and solving in a timely fashion any technical problems encountered.
The core laboratory skills required include (a) basic cell culture and microscopic imaging, (b) cutting brain slices and testing their signaling responses to ex vivo stimulation with growth factor hormones, (c) homogenizing and solubilizing tissue slices and isolating their cell membrane, cytosolic, and nuclear fractions, (d) immunoprecipitating antigens in the tissue fractions (or in exosomes from blood) and running them on Western blots, (e) extracting nuclear DNA for genotyping and mRNA for gene expression, and (f) quantifying results of Western blots, Northern blots, and PCR results. The successful candidate must keep clear, detailed records of experiments, present results cogently at laboratory meetings, be proficient in Word, Excel, Adobe Illustrator and Photoshop, and basic statistical software programs, and write research reports and sections of grant applications in publication-grade English. The employee must interact easily and respectfully with the PI, peers, and members of others laboratories at Loma Linda University and the Loma Linda VA.
If interested, please email an introductory letter and CV to Dr. Konrad Talbot, Associate Professor in Neurosurgery, Loma Linda University Medical Center at email@example.com by November 30, 2018. Finalists will be asked to provide two letters of reference from those for whom they have performed laboratory studies in recent years.
Additional Salary Information: Salary increases step-wise over the 5 years of the project.
Internal Number: 2157
About Loma Linda University Medical Center
Loma Linda University Medical Center is widely respected as a health care leader and is known for its pioneering and cutting-edge work in such areas as organ transplants, proton treatment for cancers, cardiac care, physical rehabilitation, neurology, neurosurgery and acute care. LLUMC is the largest and only Level I Trauma Center in the San Bernardino, Riverside, Inyo, and Mono counties. With a total of 507 beds, Loma Linda University Medical Center sees over 16,000 inpatients and about 470,000 outpatient visits a year.
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